Evaluation of Biochemical Parameters in Coronary Artery Patients with Covid-19 Infection
Yaroğlu, Hatice Yıldırım | Yeşil, Emrah
As a result of pneumonia brought on by coronavirus disease (COVID-19), acute myocardial infarction, and chronic cardiovascular system damage, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells via ACE2 receptors. In patients with coronary artery disease (CAD) who are positive for COVID-19, early measurement of cardiac damage through biomarkers and careful monitoring of myocardial damage that may be caused by infection should be performed. The goal of this study was to retrospectively assess the results of biochemical laboratory testing in patients with CAD and COVID-19. Biochemical laboratory results of 70 patients with CAD and COVID-19 and 70 patients only with CAD were examined retrospectively. A signifcant difference was detected between groups in terms ...
Association with serum adropin levels and isolated coronary artery ectasia in patients with stable angina pectoris
Özkan, Buğra | Örsçelik, Özcan | Yaroğlu, Hatice Yıldırım | Balcı, Şenay | Özcan, Mert Koray | Çelik, Ahmet | Özcan, İsmail Türkay
Objective: Dilation of one or more coronary artery segments to a diameter at least 1.5 times that of a normal adjacent segment is referred to as coronary artery ectasia (CAE). Adropin is a protein involved in endothelial function and is shown to have a protective effect on the regulation of cardiac functions. Atherosclerosis and endothelial dysfunction play an important role in the development of CAE. The aim of this study was to investigate the association between serum adropin levels and isolated CAE. Methods: Patients with stable angina pectoris who underwent coronary angiography (CAG) between August 2017 and July 2018 were evaluated prospectively. A total of 92 subjects were included in the study-40 patients over 18 years old and diagnosed with isolated CAE based on CAG findings and a ...
Glutathione S-transferase gene polymorphism as a susceptibility factor in smoking-related coronary artery disease
Yaroğlu, Hatice Yıldırım | Çamsarı, Ahmet | Yılmaz, Dilek Çiçek | Sucu, Nehir | Aras, Nurcan | Tamer, Lülüfer
Coronary artery disease (CAD) is the leading cause of morbidity and mortality in the world, and cigarette smoking is a major contributing factor to the disease. Glutathione S-transferase (GST) enzyme is implicated in the detoxification of carcinogens present in tobacco smoke and consequent polymorphisms in this gene may confer susceptibility to cardiovascular disease if DNA damage is important in CAD. Therefore, we examined this question in a case-control study of subjects having coronary atheroma by angiography and with a past history of myocardial infarction (MI). The study population consists of 247 healthy controls and 148 consecutive patients who had undergone coronary angiography for suspicion of coronary artery disease. DNA was extracted from whole blood, and the GSTM1 and GSTT1 pol...
Investıgatıon of the possıble role of Poly (Adp-Rıbose) polymerase pathway in Nıcotıne- Exposed Testıcular Damage
Hazır, Selin | Yaroğlu, Hatice Yıldırım | Bayram, Gül | Aşkın, Ali
Although known adverse effects of nicotine exposure on general health, it is largely consumed as cigarette smoking. Smoking has negative effects on the fertility in males; however, the molecular mechanisms affected by nicotine are largely unclear. In this study, we aimed to investigate the effect of nicotine on poly(ADP-ribose) polymerase (PARP) pathway in testicular damage. Twenty-four male C57BL/6J mice were arbitrarily categorized into three subgroups: control, sham (subcutaneous, 0.9% sterile saline), and nicotine (subcutaneous, 3 mg/kg/body weight/day) groups. After 14 days of twice-daily subcutaneous injections, the weights of the body and testes were measured. The levels of testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), cotinine (main metabolite of nicot...
The investigation of lipoprotein-related phospholipase A2 (LP-PLA2) V279F mutation in coronary artery disease
Yaroğlu, Hatice Yıldırım | Yılmaz, Dilek Çiçek | Tamer, Lülüfer
Objective: Despite advances in the treatment of cardiovascular diseases, coronary artery disease (CAD) maintains to be the leading cause of death in many nations. The media layer of normal and diseased arteries contains lipoprotein-associated phospholipase A2 (Lp-PLA2), which is mostly made by mast, T lymphocytes, and monocytes. Our research sought to define how the Lp-PLA2 and V279F gene polymorphisms relate to CAD. Materials and Methods: This study included 71 controls and 109 patients. Fasting blood glucose (FBG) and lipid profiles, were measured the enzymatic colorimetric technique. Lp-PLA2 levels were detected with ELISA. The genomic DNAs were isolated from whole blood. Real-time polymerase chain reaction (RT-PCR) with the V279F mutation detection kit was used to identify the Lp-PLA2 ...
MicroRNAs Expression Profiles in Non-Small Cell Lung Cancer
Yaroğlu, Hatice Yıldırım | Balcı, Şenay | Tamer, Lülüfer | Ayan, Erhan | Ünal, Zeynep Nil
MicroRNAs (miRNAs) are a new endogenous small non-coding RNA family that arranges expression of a few genes related in normal development as well as human diseases such as cancer. miRNAs are developing as potential diagnostic and therapeutic markers with deregulated expression in various cancers including lung cancer. In this study, we aimed to find out miRNA expression profiles and to show the relationship between non-small cell lung cancer and microRNAs levels, if there is. In the present study, the expression profiles of 740 miRNA in plasma from 31 patients and 64 healthy subjects were evaluated using high-throughput real-time quantitative polymerase chain reaction. All statistical analyses were performed using the Biogazelle's qbase PLUS 2.0 software. Our results showed that expression...