Anti-Ige Therapy Prevents Chronic Allergic Asthma-Related Deterioration of Bone Quality in Asthmatic Mice: A Biomechanical & ICP-MS Study

Nural, Yahya

Aim: Recent studies suggest an association between allergic diseases, including asthma, and bone loss. However, it is not yet clearly known whether chronic allergic asthma (CAA) cause bone deterioration and/or anti-IgE therapy used in asthma treatment prevent bone quality. Thus, the aim of the study was to investigate whether: i) CAA cause meaningful changes in bone quality and ii) anti-IgE therapy have protective effects on asthma-related bone loss and bone deterioration if any. Methods: We used a chronic inhalational exposure model of asthma in ovalbumin-sensitized BALB/c male mice (8-10 weeks-old) to generate CAA. Thirty-two mice were assigned randomly into four groups (eight mice per group): control (intact group), CAA (treated with saline), CAA+100 µg of anti IgE, and C...