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Fakülteler75
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Tıp Fakültesi75
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Dahili Tıp Bilimleri Bölümü75
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Çocuk Sağlığı ve Hastalıkları Anabilim Dalı34
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Acil Tıp Anabilim Dalı23
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İç Hastalıkları Anabilim Dalı5
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Temel Tıp Bilimleri Bölümü4
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Aile Hekimliği Anabilim Dalı4
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Çocuk Ruh Sağlığı ve Hastalıkları Anabilim Dalı4
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Klinik Bakteriyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı4
Nucleated red blood cells as predictor of all-cause mortality in emergency department
Hüseyin Narcı | Cüneyt Ayrık | Mehmet Burak Yavuz Çimen
Bacground: Nucleated red blood cells (NRBCs) are immature erythrocytes that are not normally detected in the blood of healthy adults. The detection of these cells in peripheral blood is associated with increased mortality and poor prognosis. In this study, we aimed to investigate whether NRBCs predict for all causes of death in patients admitted to the emergency department (ED). Method: This study was conducted retrospectively between January 2019 and December 2019 in academic emergency department, faculty of medicine. We included all patients who died of non-traumatic causes and The control group consisted of patients discharged from the ED. NRBCs and other laboratory parameters were compared between the two groups. The primary outcome is all-cause mortality in the ED. Multivariate log...
Determining risk factors of bleeding in patients on warfarin treatment
Evren Uygungül | Cuneyt Ayrik | Huseyin Narci | Semra Erdoğan | Ibrahim Toker | Filiz Demir | Ulas Karaaslan
Background. Warfarin is a commonly used oral anticoagulant agent. The most common adverse effects of warfarin are bleeding complications. Methods. We performed a 1-year retrospective chart review of emergency department patients using warfarin. A total of 65 patients with bleeding disorder (study group) and 63 patients without bleeding (control group) were included, making up a total of 128 subjects. Demographic data, frequency of international normalized ratio (INR) checks, and routine blood results were extracted. Logistic regression analysis was used to determine which factors were most closely associated with bleeding complications. Results. Median age was 62.0 ± 14.4 and 61.9 ± 14.5 for study group and control group, respectively. Educational status and frequency of INR checks were si...
Emergency department presentation of hemoptysis due to nail gun injury
Huseyin Narci | Seda Özer | Gülten Bozali | Cüneyt Ayrık | Ali Özdülger
Nail guns are cheap and easy-to-access devices that are common in the industry and personal use and are widely used by untrained people. Life-threatening injuries may occur after a self-accident due to the use of these devices. We report the case of a 47-year-old man who had hemoptysis due to a lung parenchymal injury after nail gun use. Computed tomography revealed focal alveolar hemorrhage. Hemodynamically stable, the patient underwent surgery. Nail guns penetrating the chest can cause life-threatening situations. In the emergency department, rapid diagnosis and treatment is vital in preventing fatal outcome. Keywords: Alveolar hemorrhage; hemoptysis; nail gun
Canlı böbrek donörlerinde renal prognoz ve sağkalımı etkileyen faktörlerin araştırılması
Şirin, Serdar.
ÖZET Canlı böbrek donörleri, nakli takiben bazı medikal sorunlarla karşılaşmaktadırlar. Kısa dönemde, enfeksiyon, kanama yeniden operasyon gibi komplikasyonlara maruz kalırlar. Uzun dönemde ise, hipertansiyon, malignansi, kronik renal hasar, psikolojik, sosyal, kardiyovasküler ve serebrovasküler sorunlarla karşı karşıya kalırlar. Bu çalımanın temel amacı; 2012-2017 yılları arasında hastanemizde yapılmış renal transplantasyon ameliyatlarında böbrek vericisi olan canlı donörlerin renal prognoz ve sağkalımını etkileyen faktörlerin incelenmesidir. Bunun için, 93 canlı böbrek donörü ve kontrol grubu için yaş ve cinsiyet uyumlu 92 sağlıklı birey çalışmaya dahil edildi. Donörlere, geçirdikleri nakil süreci ile ilgili açık uçlu 14 soru içeren bir anket verilip 25 dakika içerisinde yanıtlamaları is...
The prognostic value of immature granulocyte in patients with acute pancreatitis
Serkan Karakulak | Hüseyin Narcı | Cüneyt Ayrık | Semra Erdoğan | Enver Üçbilek
Abstract Background: Acute pancreatitis is the inflammation of the pancreas. It can range from mild forms to life-threatening severe cases. There is not yet a marker that can detect severe cases in the early period. Early diagnosis and treatment of this disease has critical importance for prognosis. In this study, we aimed to investigate the percentage of immature granulocyte (IG %) in patients with acute pancreatitis in order to predict the severity of the disease and in-hospital mortality. Method: This study was carried out retrospectively in academic emergency department (ED), faculty of medicine between 01.01.2017 and 30.06.2019. The patients were divided into three groups as mild, moderate and severe. In addition, the patients were divided into two groups: those discharged from th...
The value of serum mean platelet volume in testicular torsion
Narci H
Objective To compare the serum mean platelet volume (MPV) in patients with testicular torsion and healthy control subjects. Methods This retrospective study compared clinical and demographic data from patients who underwent surgery for testicular torsion and healthy controls. Testicular torsion was diagnosed with a physical examination and Doppler ultrasonography. Age, leukocyte count, platelet count and MPV were recorded for all participants. Results A total of 50 patients with testicular torsion and 51 healthy control subjects were enrolled. There was no significant difference in age and platelet count between the two groups. Patients with testicular torsion had a significantly higher leukocyte count and MPV, compared with controls. According to receiver operating characteristic cur...
The Impact of Organic Anion-Transporting Polypeptide (OATP) Variants on the Side Effects of Direct-Acting Antivirals in Hepatitis C Patients
Zuhal Altintas | Engin Altıntaş
Background Organic anion-transporting polypeptides (OATPs) are responsible for the cellular uptake of a broad range of endogenous compounds and xenobiotics in multiple tissues. The aim of our study was to determine whether variations in OATP1B1 and OATP1B3 affect the side effects experienced by hepatitis C patients treated with direct-acting antivirals (DAAs). Methods This study included 199 hepatitis C patients treated with DAAs. Ledipasvir/sofosbuvir or ombitasvir/paritaprevir/ritonavir ± dasabuvir and 162 control individuals without hepatitis C. Treatment-related side effects were recorded. The OATP1B1 gene variations c.388A>G and c.521T>C and the OATP1B3 gene variations c.334T>G and c.699G>A were analyzed via the polymerase chain reaction-restriction fragment length polymorphism method...
Epigenetics and Expression of the Wnt Signaling Pathway in Ulcerative Colitis
Zuhal Altintas | Mehmet Emin Erdal | Engin Altintas
Background/Aims: Secreted frizzled-related proteins (SFRPs) are antagonists that bind Wnt and inhibit signaling through this pathway. Secreted frizzled-related proteins are silenced by promoter methylation and cause hyperactivation of the Wnt pathway. In this study, the aim was to evaluate the relationship between methylation and expression of genes involved in the Wnt signaling pathway and the risk of cancer development in inflammatory bowel disease. Materials and Methods: The patient group consisted of 20 individuals who were diagnosed with left-side ulcerative colitis and under went surveillance colonoscopy; the control group consisted of 15 individuals without symptoms and endoscopic pathology who were screened for colorectal cancer. Tissue samples were obtained from inflamed and ...
Deep Learning-Based Prediction Models for the Detection of Vitamin D Deficiency and 25-Hydroxyvitamin D Levels Using Complete Blood Count Tests
Acı, Çiğdem | Acı, Mehmet
Vitamin D (VitD) is an essential nutrient that is critical for the well-being of both adults and children, and its deficiency is recognized as a precursor to several diseases. In previous studies, researchers have approached the problem of detecting vitamin D deficiency (VDD) as a single ”sufficient/deficient” classification problem using machine learning or statistics-based methods. The main objective of this paper is to predict a patient’s VitD status (i.e., sufficiency, insufficiency, or deficiency), severity of VDD (i.e., mild, moderate, or severe), and 25-hydroxyvitamin D (25(OH)D) level in a separate deep learning (DL)-based models. An original dataset consisting of complete blood count (CBC) tests from 907 patients, including 25(OH)D concentrations, collected from a public health la...
Elektrik çarpması nedeniyle acil servise başvuran hastaların geriye dönük incelenmesi
Turan, Cumali.
ÖZET Elektrik yaralanmaları tüm dünyada görülen önemli sağlık sorunlarından birisidir. Bu yaralanmalar, küçük deri yanıklarından yaĢamı tehdit eden iç organ hasarına neden olabilirler. Bu çalıĢmanın amacı elektrik yaralanmaları ile acil servise baĢvuran hastaların klinik bilgilerini değerlendirmektir. Bu çalıĢmada, Mersin Üniversitesi Acil Tıp Anabilim Dalı‟na 01.01.2012- 31.12.2016 tarihleri arasında elektrik yaralanması nedeniyle baĢvuran hastalar retrospektif olarak incelendi. Hastaların, demografik, klinik ve laboratuvar bulguları kaydedildi. ÇalıĢmaya, 103‟ü erkek olmak üzere toplam 124 hasta alındı. Tüm hastaların yaĢ ortalamaları 31,5 ± 11,2 idi Hastaların %85,5‟i düĢük voltaj, %14,5‟i ise yüksek voltaja maruz kalmıĢtı. Yüksek voltajlı yaralanmayla gelen vakaların tamamının iĢ kazas...
Meme kanserinde dinamik manyetik rezonans görüntüleme bulguları ile histopatolojik prognostik faktörler arasındaki ilişkinin değerlendirilmesi
Yüksek, Hasan Hüsnü.
ÖZET Çalışmamızın amacı invaziv meme kanserlerinin dinamik manyetik rezonans görüntülemedeki (MRG) morfolojik ve kinetik özellikleri ile klasik histopatolojik ve moleküler prognostik faktörler ve moleküler alt gruplar arasındaki ilişkiyi değerlendirmektir. Çalışmamızda, Ocak 2013-Ocak 2018 tarihleri arasında, cerrahi olarak invaziv meme kanseri tanısı alan 90 olguya ait 93 meme tümörünün MRG bulguları retrospektif değerlendirilmiş ve bulgular prognostik faktörler ile karşılaştırılmıştır. Tümörlerin dinamik meme MRG’deki karakterizasyonu 2013 “Meme Görüntüleme Raporlama ve Veri Sistemi” (Breast Imaging Reporting and Data System - BIRADS) MRG terminolojisine göre yapılmıştır. Tümörün patolojik çapı, aksiller lenf nodu ve lenfovasküler invazyon durumu ve histolojik grade klasik histopatolojik...
Sağlık Bilimleri Alanında Okuyan Öğrencilerin Serviks Kanseri ve Human Papilloma Virüs Aşısı Hakkındaki Bilgi, Tutum ve Farkındalık Düzeyleri
ÇELİK, HATİCE IRMAK | KARAHAN, FERYAL | ÇETİN ,HACER | TAŞDELEN, BAHAR
Amaç: Serviks kanseri, dünya genelinde kadınlarda en sık görülen ve en sık ölüme neden olan dördüncü kanser türüdür. Başlıca risk faktörü ise Human Papilloma Virüsüdür (HPV). Çalışmanın amacı, sağlık bilimleri öğrencilerinin serviks kanseri ve HPV aşısı hakkındaki bilgi düzeyini, tutumunu ve farkındalığını belirlemekti. Yöntem: Çalışma, bir üniversitenin tıp ve hemşirelik fakültelerinde eğitim gören 1101 öğrenci ile 15 Aralık 2017 – 15 Aralık 2018 arasında yürütüldü. Katılımcıların demografik özelliklerinin, HPV, pap-smear testi, HPV aşısı ve serviks kanseri ile ilgili bilgi düzeylerinin, serviks kanseri ve HPV aşısı hakkında tutumlarının ve farkındalık düzeylerinin sorgulandığı bir anket kullanıldı. Bulgular: Çalışmaya yaş ortalaması 21.4 yıl olan 1101 öğrenci katıldı; 559'u ...
The role of immature granulocyte percentage in predicting acute chest syndrome and the severity of the vaso-occlusive crisis in sickle cell disease
Karahan,Feryal | Ünal,Selma | Bozlu, Gülçin
Background: Sickle cell disease (SCD) is an inflammatory disease that can result in both chronic and acute inflammation. Immature granulocytes (IG) are not-yet-mature white blood cells that can be easily detected in complete blood count (CBC) tests. In recent studies it has been suggested that IG may play a role in determining the prognosis of inflammatory diseases. The aim of our study was to investigate the role of IG percentage on predicting acute chest syndrome (ACS) and the severity of vaso-occlusive crisis (VOC) in patients with SCD. Methods: The study cohort consisted of 49 SCD patients admitted to the emergency department for VOC. If symptoms did not regress despite appropriate treatment including hydration and analgesia, they were hospitalized. Patients whose symptoms regressed...
The psychosocial status of siblings and mothers of children with cancer from the perspective of mothers
İLTER ,BAHADUR EVİN | KARAHAN, FERYAL | ÖZDEMİR, ASENA AYÇA
Aims: In the low/middle income countries (LMIC), a few of health centers provide psychological support to siblings and mothers of children with cancer. The aim of study was to draw attention to psychosocial status of siblings and mothers of children with cancer in a LMIC. Methods: The study was a case-control study which was conducted at a tertiary center in Mersin, Turkey. The sample consisted of two groups as follows; siblings of children with cancer (n=39) were included as study group and children without cancer diagnosis in family (n=49) were included as control group. Behavioral problems of the children were evaluated with the Child Behavior Checklist 4-18. Beck Depression Inventory (BDI) and Multidimensional Perceived Social Support Scale (MSPSS) were used for maternal depressive sy...
Toxic Skin Reactions Should Be Differentiated from Allergic Reactions to Chemotherapeutic Drugs in Children: A Case Series and Review of the Literature
Kont Özhan,Aylin | Arikoglu,Tuğba | Karahan,Feryal | Gökalp Satıcı,Fadime Eda | Tokmeci,Nazan | İlhan Yalaki,Aysu | Akbey, Veysi | Yasemin Yuyucu Karabulut | Ünal,Selma | Kuyucu,Semanur
Background: Chemotherapeutic drugs can lead to a wide spectrum of cutaneous findings, ranging from nonimmune toxic reactions to severe immune-mediated hypersensitivity reactions. The aim of this study was to evaluate the clinical, histopathological features, and prognosis of toxic skin reactions to chemotherapeutic drugs and to compare them with characteristics of immune-mediated reactions in children with malignancies. Methods: The medical records of all children with cancer who experienced skin reactions after chemotherapy administration and diagnosed as a toxic skin reaction between 2010 and 2022 were retrospectively analyzed. The diagnosis was re-evaluated and differentiated from other similar disorders by using clinical manifestations, photodocumentation, and histopathological finding...
Sickle Cell Disease and Psychosocial Well-Being: Comparison of Patients With Preclinical and Clinical Avascular Necrosis of the Femoral Head
Tezol,Özlem | Karahan,Feryal | Unal,Selma
Aim: Sickle cell disease (SCD) has significant adverse psychosocial impacts in childhood. Patients with SCD may be affected by avascular necrosis (AVN) and the most commonly involved site is the femoral head. We aimed to conduct a comparative investigation of the psychosocial well-being of pediatric SCD patients with preclinical and clinical femoral head AVN. Materials and Methods: Patients with homozygous SCD and healthy peers aged 7-17 years were included in this cross-sectional study. Psychosocial well-being was assessed by the Strengths and Difficulties Questionnaire (SDQ), parent version. SDQ scores were compared between the groups. Results: A total of 74 mother–child couples were enrolled in this study. The SCD with clinical AVN (stages I-IV) group consisted of 17 patients, SCD with...