-
Mersin Universitesi Saglik Bilimleri Dergisi3
-
Annals of Hematology1
-
Dermatitis1
-
Journal of Clinical Research in Pediatric Endocrinology1
-
Journal of Health Sciences and Medicine1
-
Journal of Pediatric Hematology/Oncology1
-
MERSİN ÜNİVERSİTESİ SAĞLIK BİLİMLERİ DERGİSİ1
-
Mersin Üniversitesi Sağlık Bilimleri Dergisi1
-
Pediatric Surgery International1
-
Pediatrics International1
Sağlık Bilimleri Alanında Okuyan Öğrencilerin Serviks Kanseri ve Human Papilloma Virüs Aşısı Hakkındaki Bilgi, Tutum ve Farkındalık Düzeyleri
ÇELİK, HATİCE IRMAK | KARAHAN, FERYAL | ÇETİN ,HACER | TAŞDELEN, BAHAR
Amaç: Serviks kanseri, dünya genelinde kadınlarda en sık görülen ve en sık ölüme neden olan dördüncü kanser türüdür. Başlıca risk faktörü ise Human Papilloma Virüsüdür (HPV). Çalışmanın amacı, sağlık bilimleri öğrencilerinin serviks kanseri ve HPV aşısı hakkındaki bilgi düzeyini, tutumunu ve farkındalığını belirlemekti. Yöntem: Çalışma, bir üniversitenin tıp ve hemşirelik fakültelerinde eğitim gören 1101 öğrenci ile 15 Aralık 2017 – 15 Aralık 2018 arasında yürütüldü. Katılımcıların demografik özelliklerinin, HPV, pap-smear testi, HPV aşısı ve serviks kanseri ile ilgili bilgi düzeylerinin, serviks kanseri ve HPV aşısı hakkında tutumlarının ve farkındalık düzeylerinin sorgulandığı bir anket kullanıldı. Bulgular: Çalışmaya yaş ortalaması 21.4 yıl olan 1101 öğrenci katıldı; 559'u ...
Different Presentations of Patients with Transcobalamin II Deficiency: A Single-Center Experience from Turkey
Ünal,Selma | Karahan,Feryal | Arıkoğlu,Tuğba | Akar,Asuman | Kuyucu,Semanur
Objective: Transcobalamin II deficiency is a rare autosomal recessive disease characterized by decreased cobalamin availability, which in turn causes accumulation of homocysteine and methylmalonic acid. The presenting clinical features are failure to thrive, diarrhea, megaloblastic anemia, pancytopenia, neurologic abnormalities, and also recurrent infections due to immune abnormalities in early infancy. Materials and methods: Here, we report the clinical and laboratory features of six children with transcobalamin II deficiency who were all molecularly confirmed. Results: The patients were admitted between 1 and 7 months of age with anemia or pancytopenia. Unexpectedly, one patient had a serum vitamin B12 level lower than the normal range and another one had nonsignificantly elevated ...
Association between serum cytokine levels with pulp necrosis and apical periodontitis in sickle cell disease
Yilmaz,Melis | Aksu,Seçkin | Karahan,Feryal | Ertaş,Elif | Ünal,Selma
This study’s objective was to assess the relationship between serum cytokine levels and the occurrence of pulp necrosis (PN) and apical periodontitis (AP) in adolescents with Sickle Cell Disease (SCD). A total of 52 adolescents, including 29 individuals diagnosed with SCD, participated in the study. Serum cytokine levels including IL-1, IL-2, IL-4, IL-6, IL-1β, IL-8, IL-10, IL-17, and TNF-α were analyzed. Radiological and intraoral dental examinations were conducted on the same day. Electric pulp testing and cold tests were conducted on all intact crowned teeth to assess the presence of PN. Periapical index scores were derived from panoramic and periapical radiographs to identify teeth exhibiting AP. Statistical analyses were carried out using Student’s t-test, Chi-square test, Spearman co...
The role of immature granulocyte percentage in predicting acute chest syndrome and the severity of the vaso-occlusive crisis in sickle cell disease
Karahan,Feryal | Ünal,Selma | Bozlu, Gülçin
Background: Sickle cell disease (SCD) is an inflammatory disease that can result in both chronic and acute inflammation. Immature granulocytes (IG) are not-yet-mature white blood cells that can be easily detected in complete blood count (CBC) tests. In recent studies it has been suggested that IG may play a role in determining the prognosis of inflammatory diseases. The aim of our study was to investigate the role of IG percentage on predicting acute chest syndrome (ACS) and the severity of vaso-occlusive crisis (VOC) in patients with SCD. Methods: The study cohort consisted of 49 SCD patients admitted to the emergency department for VOC. If symptoms did not regress despite appropriate treatment including hydration and analgesia, they were hospitalized. Patients whose symptoms regressed...
The psychosocial status of siblings and mothers of children with cancer from the perspective of mothers
İLTER ,BAHADUR EVİN | KARAHAN, FERYAL | ÖZDEMİR, ASENA AYÇA
Aims: In the low/middle income countries (LMIC), a few of health centers provide psychological support to siblings and mothers of children with cancer. The aim of study was to draw attention to psychosocial status of siblings and mothers of children with cancer in a LMIC. Methods: The study was a case-control study which was conducted at a tertiary center in Mersin, Turkey. The sample consisted of two groups as follows; siblings of children with cancer (n=39) were included as study group and children without cancer diagnosis in family (n=49) were included as control group. Behavioral problems of the children were evaluated with the Child Behavior Checklist 4-18. Beck Depression Inventory (BDI) and Multidimensional Perceived Social Support Scale (MSPSS) were used for maternal depressive sy...
Toxic Skin Reactions Should Be Differentiated from Allergic Reactions to Chemotherapeutic Drugs in Children: A Case Series and Review of the Literature
Kont Özhan,Aylin | Arikoglu,Tuğba | Karahan,Feryal | Gökalp Satıcı,Fadime Eda | Tokmeci,Nazan | İlhan Yalaki,Aysu | Akbey, Veysi | Yasemin Yuyucu Karabulut | Ünal,Selma | Kuyucu,Semanur
Background: Chemotherapeutic drugs can lead to a wide spectrum of cutaneous findings, ranging from nonimmune toxic reactions to severe immune-mediated hypersensitivity reactions. The aim of this study was to evaluate the clinical, histopathological features, and prognosis of toxic skin reactions to chemotherapeutic drugs and to compare them with characteristics of immune-mediated reactions in children with malignancies. Methods: The medical records of all children with cancer who experienced skin reactions after chemotherapy administration and diagnosed as a toxic skin reaction between 2010 and 2022 were retrospectively analyzed. The diagnosis was re-evaluated and differentiated from other similar disorders by using clinical manifestations, photodocumentation, and histopathological finding...
Evaluation of Intestinal Microbiota in Children With Sickle Cell Disease
Karahan,Feryal | Tezol,Özlem | Kuyucu,Necdet | Türkegün,Merve | Ünal,Selma
Background and Aims: Sickle cell disease (SCD) is a chronic hemolytic anemia that may be life-threatening due to multisystemic effects. Identification of the factors which affect the pathophysiology of the disease is important in reducing mortality and morbidity. This study aimed to determine gut microbial diversity in children and adolescents with SCA compared with healthy volunteers and to evaluate the clinical impact of microbiota. Materials and Methods: The study included 34 children and young adolescents with SCD and 41 healthy volunteer participants. The microbiome was assessed by 16S rRNA sequencing in stool samples. Laboratory parameters of all participants, such as complete blood count and C-reactive protein values and clinical characteristics of SCD patients, were determin...
Sickle Cell Disease and Psychosocial Well-Being: Comparison of Patients With Preclinical and Clinical Avascular Necrosis of the Femoral Head
Tezol,Özlem | Karahan,Feryal | Unal,Selma
Aim: Sickle cell disease (SCD) has significant adverse psychosocial impacts in childhood. Patients with SCD may be affected by avascular necrosis (AVN) and the most commonly involved site is the femoral head. We aimed to conduct a comparative investigation of the psychosocial well-being of pediatric SCD patients with preclinical and clinical femoral head AVN. Materials and Methods: Patients with homozygous SCD and healthy peers aged 7-17 years were included in this cross-sectional study. Psychosocial well-being was assessed by the Strengths and Difficulties Questionnaire (SDQ), parent version. SDQ scores were compared between the groups. Results: A total of 74 mother–child couples were enrolled in this study. The SCD with clinical AVN (stages I-IV) group consisted of 17 patients, SCD with...
Metachronous Synovial Sarcoma After Treatment of Mixed Germ Cell Tumor in a Child with Complete Gonadal Dysgenesis
KARAHAN FERYAL | ÇITAK ELVAN ÇAĞLAR | yaman Emel | ALAKAYA MEHMET | SAĞCAN MÜMÜN FATİH | YILMAZ EDA BENGİ | bozkurt funda | GÜRSES İCLAL | BALCI YÜKSE
Patients with complete XY gonadal dysgenesis (GD) show a high predisposition to germ cell tumors (GCT). Patients with coexistence of GCT and GD have been reported previously. Here we present a 15-year-old girl with mixed GCT and GD who also developed an intra-abdominal synovial sarcoma one year after the treatment. This is the first report, to our knowledge, of synovial sarcoma associated with XY GD.
Toxic Skin Reactions Should Be Differentiated from Allergic Reactions to Chemotherapeutic Drugs in Children: A Case Series and Review of the Literature
Kont Özhan,Aylin | Demirhan,Ali | Arikoglu,Tuğba | Karahan,Feryal | Gökalp Satıcı,Fadime Eda | Tokmeci,Nazan | İlhan Yalaki,Aysu | Akbey, Veysi | Yuyucu Karabulut,Yasemin | Ünal,Selma | Kuyucu,Semanur
Background: Chemotherapeutic drugs can lead to a wide spectrum of cutaneous findings, ranging from nonimmune toxic reactions to severe immune-mediated hypersensitivity reactions. The aim of this study was to evaluate the clinical, histopathological features, and prognosis of toxic skin reactions to chemotherapeutic drugs and to compare them with characteristics of immune-mediated reactions in children with malignancies. Methods: The medical records of all children with cancer who experienced skin reactions after chemotherapy administration and diagnosed as a toxic skin reaction between 2010 and 2022 were retrospectively analyzed. The diagnosis was re-evaluated and differentiated from other similar disorders by using clinical manifestations, photodocumentation, and histopathological finding...
Diagnostic evaluation of hematologic inflammatory markers forearthquake-related crush syndrome in pediatric patients
DURAK ,FATMA | TEZOL, ÖZLEM | BOZLU, GÜLÇİN | SÜRMELİ ,DÖVEN SERRA | ALAKAYA, MEHMET | MISIRLIOĞLU, ÇELİK MERVE | YEŞİL, EDANUR | KARAHAN, FERYAL | KILLI, İSA
Background: In order to ensure the early treatment of crush syndrome in emergencydepartments in times of disaster, there is a need for tools that will accelerate andfacilitate the diagnosis. We aimed to assess hematologic inflammatory markers aspotential diagnostic indicators of crush syndrome in pediatric patients injured bybeing trapped under debris in the 2023 Turkey–Syria earthquake.Methods: This analytical study included 123 pediatric cases with a history of beingunder debris. Patients were divided into three groups according to serum creatinekinase (CK) values and clinical characteristics at the time of admission: traumagroup with a normal CK level (n = 33), crush injury group (n = 30), and crush syndromegroup (n = 64). Complete blood count results sent at the time of presentation to...
Increased serum YKL-40 levels in children with sickle cell disease
Akbey,Veysi | Ünal,Selma | Tezol, Özlem | Bahar Taşdelen | Karahan,Feryal
Background: YKL-40 is a glycoprotein secreted by various cell lines during inflammation and vascular dysfunction. Sickle cell disease (SCD) also involves inflammation and endothelial dysfunction processes. Thus, we aimed to assess the levels of YKL-40 in pediatric SCD patients. Methods: We evaluated serum levels of YKL-40 in children with steady state SCD and those with vaso-occlusive crisis (VOC) episodes and compared them with healthy subjects. Results: Overall, 33 children with SCD and 33 healthy controls participated in this study. Serum YKL-40 concentrations of children with steady state SCD were significantly higher than the concentrations found in the healthy controls (median [Q1-Q3]: 71.0 [53.3-133.3] vs. 43.6 [37.9-69.9] ng/mL, p=0.001). Seventeen of the 33 children with SCD...
Evaluation of the relationship between intravascular hemolysis and clinical manifestations in sickle cell disease: decreased hemopexin during vaso-occlusive crises and increased inflammation in acute chest syndrome
Yildirim,Nazim | Unal,Selma | Karahan,Feryal
The aims of this study were to determine the possible relationships between the levels of hemin, hemopexin, acid sphingomyelinase, nitrite/nitrate (NOx), and other parameters in patients with SCD and to assess whether they were associated with vaso-occlusive crises (VOCs) or acute chest syndrome (ACS). Patients with SCD (homozygous or sickle beta-thalassemia) who were confirmed to have VOC or ACS were included. Blood samples were obtained at admission, on the third day of hospitalization, and at steady state. Demographic characteristics, pain (visual analog scale), complication history, complete blood count, lactate dehydrogenase, and C-reactive protein levels were recorded. Hemin, hemopexin, acid sphingomyelinase, and NOx were measured via ELISA. A total of 31 patients (22 VOC, 9 ACS) wer...
Orak Hücre Anemisinde Patofizyoloji
KARAHAN, FERYAL | ÜNAL, SELMA
ÖZET Orak hücre hastalığı, çok faktörlü ve yalnızca kısmen anlaşılmış bir patofizyolojiye sahip, yaşamı tehdit eden bir sağlık sorunudur. Hastalığın patofizyolojisine; HbS polimerizasyona bağlı hemoliz ve oraklaşma, vazo-oklüzyona bağlı iskemi-reperfüzyon hasarı, endotel disfonksiyona bağlı vaskülopati ve steril inflamasyon arasındaki etkileşim katkıda bulunur. Birçok yönü hala bilinmemekle birlikte, orak hücre hastalığının patofizyolojisinin çok faktörlü olduğu ve dinamik olaylarla desteklendiği düşünülmektedir. ABSTRACT Sickle cell disease is a life-threatening health problem with a multifactorial and only partially understood pathophysiology. The pathophysiology of the disease; the interaction between hemolysis and sickling due to HbS polymerization, ischemia-reperfusion injury due to...
Beta talasemi hastalarında immatür granülosit sayısı kemik iliği aktivasyonunu değerlendirmede pratik bir belirteç olabilir mi?
İNCE ,DURHAN BANU | KARAHAN, FERYAL | AKDENİZ, AYDAN | ünal, selma
Amaç: Çalışmamızda çocuk ve erişkin beta talasemi major ve intermedia hastalarımızın immatür granülosit ve immatür granülosit yüzdelerinin kemik iliği aktivasyonlarını değerlendirmede pratik bir belirteç olarak kullanılıp kullanılamayacağını araştırmayı amaçladık. Yöntem: Ocak 2017-Aralık 2021 tarihleri arasında Mersin Üniversitesi Tıp Fakültesi Çocuk ve Erişkin Hematoloji kliniğinde takipli 38 Beta talasemi major ve 12 Beta talasemi intermedia hastasının yaş, hemoglobin (gr/dl), hematokrit, beyaz küre sayısı (x103/μL), trombosit değeri (x103/μL), immatür granülosit sayısı ( x103/μL) , immatür granülosit yüzdesi (%), ferritin değeri (ng/mL), şelasyon durumu, transfüzyon sıklığı ve düzeni, son bir yıldaki ortalama hemoglobin düzeyi gibi parametreleri incelendi. Düzenli transfüzyon alan ve a...
Orak Hücre Hastalığında Ağrılı Kriz Yönetimi
Karahan,Feryal | Ünal,Selma
Orak hücre hastalığı dünyada en sık görülen hemoglobinopatilerden biridir. Hastalık hayatı tehdit edebilen akut komlikasyonlar ve çeşitli organlarda kronik hasarlar ile sonuçlanabilen kronik hemolitik anemi ile karakterizedir. Orak hücre hastalığının klinik seyri hastalar arasında çeşitlilik gösterir. Bazı hastalarda şiddetli ağrılı krizler ile sağlık kuruluşlarına sık başvuru ve komplikasyonlar gelişirken, diğerleri daha hafif klinik bulgular sergiler. Hastaların karşılaştığı en önemli sorunlardan biri, damar tıkayıcı kriz ve buna bağlı doku iskemisinden kaynaklanan ağrılı krizlerdir. Ağrılı kriz, hastalığın öngörülemeyen, tekrarlayan, sıklıkla kalıcı olan ve tedavi için pek çok kez ağrı kesici kullanımını gerektiren, genellikle zor ve karmaşık bir süreçtir. Bu sürecin en iyi şekilde yöne...